Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Heavy chain-only antibodies (HCAbs) do not associate with light chains and their VH regions are functional as single domains, forming the smallest active antibody fragment. These VH regions are ideal building blocks for a variety of antibody-based biologics because they tolerate fusion to other mole...

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Bibliographic Details
Main Authors: Starlynn C. Clarke, Biao Ma, Nathan D. Trinklein, Ute Schellenberger, Michael J. Osborn, Laure-Hélène Ouisse, Andrew Boudreau, Laura M. Davison, Katherine E. Harris, Harshad S. Ugamraj, Aarti Balasubramani, Kevin H. Dang, Brett Jorgensen, Heather Anne N. Ogana, Duy T. Pham, Payal P. Pratap, Preethi Sankaran, Ignacio Anegon, Wim C. van Schooten, Marianne Brüggemann, Roland Buelow, Shelley Force Aldred
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
heavy chain antibodies
VH domains
domain antibodies
antibody discovery platform
next-generation sequencing
repertoire sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03037/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03037/full

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