Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p

Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p

ObjectivesThe aim of this study was to investigate the effects of exosomes isolated from human bone marrow mesenchymal stem cells (BMSCs) on osteoarthritis (OA) and a competitive endogenous RNA (ceRNA) network.MethodsExosomes were isolated from human BMSCs and characterized by transmission electron...

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Bibliographic Details
Main Authors: Xiuhui Wang, Zhuokai Li, Yin Cui, Xu Cui, Cheng Chen, Zhe Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoarthritis
exosomes
GRPR
miR-6515-5p
lncRNA LYRM4-AS1
IL-1β-induced chondrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.644380/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.644380/full

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