New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7 activity. The synthesis of twenty-five flavonoids...

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Bibliographic Details
Main Authors: Joana Moreira, Diana Ribeiro, Patrícia M. A. Silva, Nair Nazareth, Madalena Monteiro, Andreia Palmeira, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
flavonoids
O-heterocycles
alkylation
antitumor activity
apoptosis
caspase activators
Online Access:http://www.mdpi.com/1420-3049/24/1/129

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http://www.mdpi.com/1420-3049/24/1/129

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