Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemias⃞

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemias⃞

Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content by inducing reverse cholesterol transport, increasing bile acid production, and inhibiting intestinal cholesterol absorption. Most of them, ho...

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Bibliographic Details
Main Authors: Adelheid Kratzer, Marlene Buchebner, Thomas Pfeifer, Tatjana M. Becker, Georg Uray, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Birgit Ebner, Prakash G. Chandak, Rajendra S. Kadam, Emine Calayir, Nora Rathke, Helmut Ahammer, Branislav Radovic, Michael Trauner, Gerald Hoefler, Uday B. Kompella, Guenter Fauler, Moshe Levi, Sanja Levak-Frank, Gerhard M. Kostner, Dagmar Kratky
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Journal of Lipid Research
Subjects:
atherogenesis
liver X receptor
cholesterol catabolism
ABC transporter
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520414555

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http://www.sciencedirect.com/science/article/pii/S0022227520414555

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