Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality

Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have revealed that extracellular ATP, through its selective receptor P2X7 (P2X7R), is esse...

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Bibliographic Details
Main Authors: Carlos Martínez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-García, Álvaro Sebastián-Serrano, Lisardo Boscá, Miguel Díaz-Hernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
senile plaques
neuroinflammation
LPS
BzATP
ATP
Alzheimer disease
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00143/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00143/full

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