Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons

Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons

Abstract Hypersynchronous neuronal excitation manifests clinically as seizure (ictogenesis), and may recur spontaneously and repetitively after a variable latency period (epileptogenesis). Despite tremendous research efforts to describe molecular pathways and signatures of epileptogenesis, molecular...

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Bibliographic Details
Main Authors: K. Kiese, J. Jablonski, J. Hackenbracht, J. K. Wrosch, T. W. Groemer, J. Kornhuber, I. Blümcke, K. Kobow
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Acta Neuropathologica Communications
Subjects:
Primary neuronal cell culture
Hippocampus
Epigenetic
Cellular memory
Epilepsy
Online Access:http://link.springer.com/article/10.1186/s40478-017-0485-x

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http://link.springer.com/article/10.1186/s40478-017-0485-x

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