Homeostatically maintained resting naïve CD4+ T cells resist latent HIV reactivation

Homeostatically maintained resting naïve CD4+ T cells resist latent HIV reactivation

Homeostatic proliferation (HSP) is a major mechanism by which long-lived naïve and memory CD4+ T cells are maintained in vivo and suggested to contribute to the persistence of the latent HIV-1 reservoir. However, while many in vitro latency models rely on CD4+ T cells that were initially differentia...

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Bibliographic Details
Main Authors: Yasuko Tsunetsugu-Yokota, Mie Kobayashi-Ishihara, Yamato Wada, Kazutaka Terahara, Haruko Takeyama, Ai Kawana-Tachikawa, Kenzo Tokunaga, Makoto Yamagishi, Javier P Martinez, Andreas Meyerhans
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Microbiology
Subjects:
HIV
resting state
latency
homeostatic proliferation
naive CD4 T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01944/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01944/full

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