Determining a Bayesian predictive power stopping rule for futility in a non-inferiority trial with binary outcomes

Determining a Bayesian predictive power stopping rule for futility in a non-inferiority trial with binary outcomes

Background/Aims: Non-inferiority trials investigate whether a novel intervention, which typically has other benefits (i.e., cheaper or safer), has similar clinical effectiveness to currently available treatments. In situations where interim evidence in a non-inferiority trial suggests that the novel...

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Bibliographic Details
Main Authors: Anna Heath, Martin Offringa, Petros Pechlivanoglou, Juan David Rios, Terry P. Klassen, Naveen Poonai, Eleanor Pullenayegum
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Contemporary Clinical Trials Communications
Subjects:
Non-inferiority trial
Bayesian predictive power
Stopping rule
Procedural sedation
Trial design
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865420300454

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http://www.sciencedirect.com/science/article/pii/S2451865420300454

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