Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation

Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation

Abstract Background Orexins (hypocretins, Hcrt) A and B are GPCR-binding hypothalamic neuropeptides known to regulate sleep/wake states and feeding behavior. A few studies have shown that orexin A exhibits anti-inflammatory and neuroprotective properties, suggesting that it might provide therapeutic...

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Bibliographic Details
Main Authors: Laurine Becquet, Catalina Abad, Mathilde Leclercq, Camille Miel, Laetitia Jean, Gaëtan Riou, Alain Couvineau, Olivier Boyer, Yossan-Var Tan
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Neuroinflammation
Subjects:
Orexin A
Neuropeptide
Neuro-immunomodulation
Multiple sclerosis
EAE
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-019-1447-y

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http://link.springer.com/article/10.1186/s12974-019-1447-y

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