Statistically efficient association analysis of quantitative traits with haplotypes and untyped SNPs in family studies

Statistically efficient association analysis of quantitative traits with haplotypes and untyped SNPs in family studies

Abstract Background Associations between haplotypes and quantitative traits provide valuable information about the genetic basis of complex human diseases. Haplotypes also provide an effective way to deal with untyped SNPs. Two major challenges arise in haplotype-based association analysis of family...

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Bibliographic Details
Main Authors: Guoqing Diao, Dan-yu Lin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Genetics
Subjects:
Complex diseases
EM algorithm
Gene-environment interactions
Haplotype analysis
Hardy-Weinberg equilibrium
Unphased genotype
Online Access:http://link.springer.com/article/10.1186/s12863-020-00902-x

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http://link.springer.com/article/10.1186/s12863-020-00902-x

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