ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines

ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines

Purpose: Intensive chemotherapy with daunorubicin (DNR) is associated with serious side effects in acute myeloid leukemia (AML) patients. In this study the effect of small-molecule BH3-mimetic, ABT-737, on the sensitivity of HL60 and U937 AML cell lines was investigated. Methods: The cytotoxic effe...

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Bibliographic Details
Main Authors: Hassan Dariushnejad, Nosratallah Zarghami, Mohammad Rahmati, Samaneh Ghasemali, Zohreh Sadeghi, Zahra Davoodi, Hossein Jafari Tekab, Masoud Gandomkar Ghalhar
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2014-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Acute myeloid leukemia
Daunorubicin
ABT-737
Combination
Apoptosis
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-185.pdf

Internet

http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-185.pdf

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