Reactions of Medicinal Gold(III) Compounds With Proteins and Peptides Explored by Electrospray Ionization Mass Spectrometry and Complementary Biophysical Methods

Reactions of Medicinal Gold(III) Compounds With Proteins and Peptides Explored by Electrospray Ionization Mass Spectrometry and Complementary Biophysical Methods

Electrospray ionization mass spectrometry (ESI MS) is a powerful investigative tool to analyze the reactions of metallodrugs with proteins and peptides and characterize the resulting adducts. Here, we have applied this type of approach to four experimental anticancer gold(III) compounds for which ex...

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Bibliographic Details
Main Authors: Lara Massai, Carlotta Zoppi, Damiano Cirri, Alessandro Pratesi, Luigi Messori
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Chemistry
Subjects:
anticancer metal complexes
gold
protein interaction
mass spectrometry
cytotoxic compounds
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.581648/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2020.581648/full

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