Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice

Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice

Abstract Background Potassium channel tetramerisation domain containing 9 (KCTD9), a member of KCTD family with a DNA-like pentapeptide repeat domain, was found to be increased particularly in NK cells of patients with HBV-induced acute-on-chronic liver failure (HBV-ACLF) and experimental viral fulm...

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Bibliographic Details
Main Authors: Xiaoping Zhang, Lin Zhu, Yaoyong Zhou, Aichao Shi, Hongwu Wang, Meifang Han, Xiaoyang Wan, Semvua Bukheti Kilonzo, Xiaoping Luo, Tao Chen, Qin Ning
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Immunology
Subjects:
KCTD9
Short hairpin RNA
NK cell
Liver failure
MHV-3
Online Access:http://link.springer.com/article/10.1186/s12865-018-0256-x

Internet

http://link.springer.com/article/10.1186/s12865-018-0256-x

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