Induction of GADD45α expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells

Polymethoxyflavones (PMFs), such as nobiletin and tangeretin, have a high cellular uptake rate, on account of their hydrophobicity. Nobiletin has been shown to down-regulate inflammatory gene expression, and is thus considered a promising anti-inflammatory and anti-carcinogenic agent. Most proteins...

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Bibliographic Details
Main Authors: Andy Chi-Lung Lee, Wei-Chun Hsiao, Duncan Edward Wright, Shin Yen Chong, Siew Keng Leow, Chi-Tang Ho, Cheng-Fu Kao, Yi-Chen Lo
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464613000054