Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the selective inhibitor rapamycin and ac...

Full description

Bibliographic Details
Main Authors: Morris E Feldman, Beth Apsel, Aino Uotila, Robbie Loewith, Zachary A Knight, Davide Ruggero, Kevan M Shokat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19209957/pdf/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19209957/pdf/?tool=EBI

Similar Items