Utilizing mouse optic nerve crush to examine CNS remyelination

Summary: In developing pro-myelination treatment, an important hurdle is the lack of reliable animal models for assessing de novo myelination in disease settings. We recently showed that regenerated axons in injured optic nerves fail to be myelinated, providing an animal model for this purpose. Here...

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Bibliographic Details
Main Authors: Tracey A.C.S. Suter, Jing Wang, Huyan Meng, Zhigang He
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721005025