Genome-Wide DNA Methylation Analysis Reveals Epigenetic Pattern of SH2B1 in Chinese Monozygotic Twins Discordant for Autism Spectrum Disorder

Genome-Wide DNA Methylation Analysis Reveals Epigenetic Pattern of SH2B1 in Chinese Monozygotic Twins Discordant for Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Aberrant DNA methylation has been observed in ASD but the mechanisms remain largely unknown. Here, we employed discordant monozygotic twins to investigate the contribution of DNA methylation to ASD etiology. Genome-wide DNA met...

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Bibliographic Details
Main Authors: Shuang Liang, Zhenzhi Li, Yihan Wang, Xiaodan Li, Xiaolei Yang, Xiaolei Zhan, Yan Huang, Zhaomin Gao, Min Zhang, Caihong Sun, Yan Zhang, Lijie Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroscience
Subjects:
autism spectrum disorder
monozygotic twins
discordant
DNA methylation
SH2B1
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00712/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00712/full

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