Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice

The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular domain. Due to gene splicing, a short extracellu...

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Bibliographic Details
Main Authors: Dongxue Li, Dongqing Jing, Ziyang Liu, Ying Chen, Fang Huang, Thomas Behnisch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
klotho
object recognition and location memory
hippocampal formation/hippocampus
passive avoidance memory
anti-aging
nesting behavior
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00133/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00133/full

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