Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling

Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling

Summary: Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases. However, the roles of Ogt in regulating neurogenesis remain largely unknown. Here, we show that Ogt deficiency or depletion in adult neural stem/p...

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Bibliographic Details
Main Authors: Junchen Chen, Xiaoxue Dong, Xuejun Cheng, Qiang Zhu, Jinyu Zhang, Qian Li, Xiaoli Huang, Min Wang, Liping Li, Weixiang Guo, Binggui Sun, Qiang Shu, Wen Yi, Xuekun Li
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
Ogt
O-GlcNAcylation
neurogenesis
neural stem/progenitor cells
cognition
notch
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002199

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http://www.sciencedirect.com/science/article/pii/S2211124721002199

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