Endothelial nitric oxide synthase is regulated by ERK phosphorylation at Ser602

Endothelial nitric oxide synthase is regulated by ERK phosphorylation at Ser602

eNOS (endothelial nitric oxide synthase) contains a MAPK (mitogen-activated protein kinase)-binding site associated with a major eNOS control element. Purified ERK (extracellular-signal-regulated kinase) phosphorylates eNOS with a stoichiometry of 2–3 phosphates per eNOS monomer. Phosphorylation de...

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Bibliographic Details
Main Authors: John C. Salerno, Dipak K. Ghosh, Raj Razdan, Katy A. Helms, Christopher C. Brown, Jonathan L. McMurry, Emily A. Rye, Carol A. Chrestensen
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-09-01
Series:Bioscience Reports
Subjects:
eNOS
ERK
fluorescence lifetime
MAPK
nitric oxide synthase
phosphorylation
Online Access:http://www.bioscirep.org/bsr/034/e137/bsr034e137.htm

Internet

http://www.bioscirep.org/bsr/034/e137/bsr034e137.htm

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