Increased expression of fragmented tRNA promoted neuronal necrosis

Abstract Neuronal necrosis induced by excessive glutamate release is well known to contribute morbidity and mortality in ischemic stroke. Over the past decades, strategies on targeting glutamate receptor did not achieve desirable clinical outcomes. Finding the downstream mechanism of the glutamate r...

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Bibliographic Details
Main Authors: Yanyan Cao, Kai Liu, Ying Xiong, Chunyue Zhao, Lei Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04108-6