Exogenous Hydrogen Sulfide Attenuates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Suppressing TLR4/NF-κB Pathway in H9c2 Cells

Exogenous Hydrogen Sulfide Attenuates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Suppressing TLR4/NF-κB Pathway in H9c2 Cells

Background/Aims: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) confered cardiac protection against high glucose (HG)-induced injury by inhibiting NLRP3 inflammasome activation via a specific TLR4/NF-κB pathway. Methods: H9c2 cardiac cells were exposed to 33 mM g...

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Bibliographic Details
Main Authors: Zena Huang, Xiaodong Zhuang, Chuli Xie, Xun Hu, Xiaobian Dong, Yue Guo, Shaofen Li, Xinxue Liao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hydrogen sulphide
Hyperglycemia
TLR4
NLRP3 inflammasome
Cardiac cell
Online Access:http://www.karger.com/Article/FullText/453208

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http://www.karger.com/Article/FullText/453208

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