Single-Cell in Situ RNA Analysis With Switchable Fluorescent Oligonucleotides

Single-Cell in Situ RNA Analysis With Switchable Fluorescent Oligonucleotides

Comprehensive RNA analyses in individual cells in their native spatial contexts promise to transform our understanding of normal physiology and disease pathogenesis. Here we report a single-cell in situ RNA analysis approach using switchable fluorescent oligonucleotides (SFO). In this method, transc...

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Bibliographic Details
Main Authors: Lu Xiao, Jia Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
transcriptomics
genomics
fluorescence in situ hybridization
strand displacement reactions
RNA expression
oligonucleotides
Online Access:http://journal.frontiersin.org/article/10.3389/fcell.2018.00042/full

Internet

http://journal.frontiersin.org/article/10.3389/fcell.2018.00042/full

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