Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape

Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape

Summary: Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome. However, the underlying molecular mechanism of these...

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Main Authors: Jieqiong Qu, Sabine E.J. Tanis, Jos P.H. Smits, Evelyn N. Kouwenhoven, Martin Oti, Ellen H. van den Bogaard, Colin Logie, Hendrik G. Stunnenberg, Hans van Bokhoven, Klaas W. Mulder, Huiqing Zhou
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318023

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http://www.sciencedirect.com/science/article/pii/S2211124718318023

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