A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling

A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling

Abstract Background The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian cancer stemness and chemotherapy resistance. Methods Mass spectrum anal...

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Bibliographic Details
Main Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang, Shu-Mei Liang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Biomedical Science
Subjects:
c-Kit
Prohibitin
Notch3
β-catenin
Cancer stem cells
Lipid raft domain of plasma membrane
Online Access:http://link.springer.com/article/10.1186/s12929-020-00638-x

Internet

http://link.springer.com/article/10.1186/s12929-020-00638-x

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