Deletion of the Histone Deacetylase HdaA in Endophytic Fungus <i>Penicillium chrysogenum</i> Fes1701 Induces the Complex Response of Multiple Bioactive Secondary Metabolite Production and Relevant Gene Cluster Expression

Deletion of the Histone Deacetylase HdaA in Endophytic Fungus <i>Penicillium chrysogenum</i> Fes1701 Induces the Complex Response of Multiple Bioactive Secondary Metabolite Production and Relevant Gene Cluster Expression

Epigenetic regulation plays a critical role in controlling fungal secondary metabolism. Here, we report the pleiotropic effects of the epigenetic regulator HdaA (histone deacetylase) on secondary metabolite production and the associated biosynthetic gene clusters (BGCs) expression in the plant endop...

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Bibliographic Details
Main Authors: Zhuang Ding, Haibo Zhou, Xiao Wang, Huiming Huang, Haotian Wang, Ruiyan Zhang, Zhengping Wang, Jun Han
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
metabolic regulation
roquefortine
meleagrin
endophytic fungi
<i>Penicillium chrysogenum</i>
Online Access:https://www.mdpi.com/1420-3049/25/16/3657

Internet

https://www.mdpi.com/1420-3049/25/16/3657

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