Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation “Memories”

Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation “Memories”

The directed differentiation of human cardiomyocytes (CMs) from pluripotent cells provides an invaluable model for understanding mechanisms of cell fate determination and offers considerable promise in cardiac regenerative medicine. Here, we utilize a human embryonic stem cell suspension bank, produ...

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Bibliographic Details
Main Authors: Joshua D. Tompkins, Marc Jung, Chang-yi Chen, Ziguang Lin, Jingjing Ye, Swetha Godatha, Elizabeth Lizhar, Xiwei Wu, David Hsu, Larry A. Couture, Arthur D. Riggs
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:EBioMedicine
Subjects:
Human embryonic stem cells
Pluripotent
Cardiomyocytes
Differentiation
Cardiomyogenesis
DNA methylation
Long non-coding RNA
lncRNA
Epigenetic
Methylome
Transcriptome
Mesoderm
Good manufacturing practice, GMP, epigenetic memory, WNT, hedgehog, transforming growth factor, ROR2, PDGFRα, demethylation, TET, TDG, HOX, TBOX
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300172

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http://www.sciencedirect.com/science/article/pii/S2352396416300172

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