Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice.

Chronic graft-versus-host disease (cGVHD) is a marked complication of hematopoietic stem cell transplantation, and multiple organs can be affected by cGVHD-induced inflammation and fibrosis. In clinical settings, immunosuppressive agents have been the last resort to treat cGVHD. However, it has been...

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Bibliographic Details
Main Authors: Shin Mukai, Yoko Ogawa, Hideyuki Saya, Yutaka Kawakami, Kazuo Tsubota
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6181285?pdf=render