Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Abstract Alzheimer’s disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the effects of human Presenilin 2 mutant (hPS2m) overexpression on the γ-secretase complex in the mi...

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Bibliographic Details
Main Authors: Woo Bin Yun, Jin Ju Park, Ji Eun Kim, Ji Eun Sung, Hyun Ah Lee, Jae Ho Lee, Chang Jun Bae, Dae Youn Hwang
Format: Article
Language:English
Published: BMC 2016-12-01
Series:Laboratory Animal Research
Subjects:
Alzheimer’s disease
presenilin 2
γ-secretase complex
Aβ-42 peptides
Online Access:http://link.springer.com/article/10.5625/lar.2016.32.4.249

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http://link.springer.com/article/10.5625/lar.2016.32.4.249

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