Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

BackgroundRestraining maladaptive inflammation is considered a rationale strategy to treat severe coronavirus disease-19 (COVID-19) but available studies with selective inhibitors of pro-inflammatory cytokines have not provided unequivocal evidence of survival advantage. Late administration is commo...

Full description

Bibliographic Details
Main Authors: Emanuel Della-Torre, Marco Lanzillotta, Corrado Campochiaro, Giulio Cavalli, Giacomo De Luca, Alessandro Tomelleri, Nicola Boffini, Rebecca De Lorenzo, Annalisa Ruggeri, Patrizia Rovere-Querini, Antonella Castagna, Giovanni Landoni, Moreno Tresoldi, Fabio Ciceri, Alberto Zangrillo, Lorenzo Dagna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
COVID-19
SARS-CoV-2
interleukin-6
interleukin-1
sarilumab
anakinra
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.675678/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.675678/full

Similar Items