Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis

Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis

Abstract Myelin basic protein (MBP) and its interaction with lipids of the myelin sheath plays an important part in the pathology of multiple sclerosis (MS). Previous studies observed that changes in the myelin lipid composition lead to instabilities and enhanced local curvature of MBP-lipid multila...

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Bibliographic Details
Main Authors: Benjamin Krugmann, Aurel Radulescu, Marie-Sousai Appavou, Alexandros Koutsioubas, Laura R. Stingaciu, Martin Dulle, Stephan Förster, Andreas M. Stadler
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-73671-3

Internet

https://doi.org/10.1038/s41598-020-73671-3

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