Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo

Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo

(1) Background: Antifolate methotrexate (MTX) is the most common disease-modifying antirheumatic drug (DMARD) for treating human rheumatoid arthritis (RA). The mitochondrial-produced formate is essential for folate-mediated one carbon (1C) metabolism. The impacts of MTX on formate homeostasis in unk...

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Bibliographic Details
Main Authors: Nga-Lai Sou, Yu-Hsuan Huang, Der-Yuan Chen, Yi-Ming Chen, Feng-Yao Tang, Hsin-An Ko, Yi-Hsuan Fan, Yi-Ying Lin, Yi-Cheng Wang, Hui-Ming Chih, Barry Shane, Wen-Nan Huang, En-Pei Isabel Chiang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
metabolism
methotrexate
therapeutic drug monitoring
folinate
one carbon metabolism
rheumatoid arthritis
Online Access:https://www.mdpi.com/1422-0067/22/3/1350

Internet

https://www.mdpi.com/1422-0067/22/3/1350

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