Family’s History Based on the <i>CDH1</i> Germline Variant (c.360delG) and a Suspected Hereditary Gastric Cancer Form

Family’s History Based on the <i>CDH1</i> Germline Variant (c.360delG) and a Suspected Hereditary Gastric Cancer Form

Hereditary diffuse gastric cancer (HDGC) is a cancer susceptibility syndrome caused by germline pathogenic variant in <i>CDH1</i>, the gene encoding E-cadherin. The germline loss-of-function variants are the only proven cause of the cancer syndrome HDGC, occurring in approximately 10–18%...

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Bibliographic Details
Main Authors: Laura Caggiari, Mara Fornasarig, Mariangela De Zorzi, Renato Cannizzaro, Agostino Steffan, Valli De Re
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>CDH1</i>
E-cadherin
HDGC
hereditary gastric cancer
genetic counseling
Online Access:https://www.mdpi.com/1422-0067/21/14/4904

Internet

https://www.mdpi.com/1422-0067/21/14/4904

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