Genomic Analysis of Natural Rough <i>Brucella</i> <i>melitensis</i> Rev.1 Vaccine Strains: Identification and Characterization of Mutations in Key Genes Associated with Bacterial LPS Biosynthesis and Virulence

Genomic Analysis of Natural Rough <i>Brucella</i> <i>melitensis</i> Rev.1 Vaccine Strains: Identification and Characterization of Mutations in Key Genes Associated with Bacterial LPS Biosynthesis and Virulence

<i>Brucella</i> species are facultative intracellular bacteria that cause brucellosis, a zoonotic world-wide disease. The live attenuated <i>B. melitensis</i> Rev.1 vaccine strain is widely used for the control of brucellosis in the small ruminant population. However, Rev.1 i...

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Bibliographic Details
Main Authors: David Kornspan, Regina Lubkovskaia, Shubham Mathur, Adva Yeheskel, Mali Salmon-Divon
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Brucella melitensis</i> Rev.1
vaccine
comparative genomic analysis
LPS genetics
virulence attenuation
Online Access:https://www.mdpi.com/1422-0067/21/24/9341

Internet

https://www.mdpi.com/1422-0067/21/24/9341

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