Whole-Inactivated Influenza Virus Is a Potent Adjuvant for Influenza Peptides Containing CD8+ T Cell Epitopes

Whole-Inactivated Influenza Virus Is a Potent Adjuvant for Influenza Peptides Containing CD8+ T Cell Epitopes

Influenza peptide antigens coding for conserved T cell epitopes have the capacity to induce cross-protective influenza-specific immunity. Short peptide antigens used as a vaccine, however, often show poor immunogenicity. In this study, we demonstrate that whole-inactivated influenza virus (WIV) acts...

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Bibliographic Details
Main Authors: Peter C. Soema, Sietske K. Rosendahl Huber, Geert-Jan Willems, Ronald Jacobi, Marion Hendriks, Ernst Soethout, Wim Jiskoot, Jørgen de Jonge, Josine van Beek, Gideon F. A. Kersten, Jean-Pierre Amorij
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
whole-inactivated influenza virus
adjuvant
T cell peptide
CTL
design of experiments
formulation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00525/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00525/full

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