Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.

Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.

Infections with the picornavirus, human rhinovirus (HRV), are a major cause of wheezing illnesses and asthma exacerbations. In developing a murine model of picornaviral airway infection, we noted the absence of murine rhinoviruses and that mice are not natural hosts for HRV. The picornavirus, mengov...

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Bibliographic Details
Main Authors: Louis A Rosenthal, Renee J Szakaly, Svetlana P Amineva, Yina Xing, Marchel R Hill, Ann C Palmenberg, James E Gern, Ronald L Sorkness
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3280220?pdf=render

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http://europepmc.org/articles/PMC3280220?pdf=render

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