Two base pair deletion in IL2 receptor γ gene in NOD/SCID mice induces a highly severe immunodeficiency

Two base pair deletion in IL2 receptor γ gene in NOD/SCID mice induces a highly severe immunodeficiency

Abstract Genome editing has recently emerged as a powerful tool for generating mutant mice. Small deletions of nucleotides in the target genes are frequently found in CRISPR/Cas9 mediated mutant mice. However, there are very few reports analyzing the phenotypes in small deleted mutant mice generated...

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Bibliographic Details
Main Authors: Inseon Bak, Doo-Jin Kim, Hyoung-Chin Kim, Hye-Jun Shin, Eunhye Yu, Kyeong-Won Yoo, Dae-Yeul Yu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Laboratory Animal Research
Subjects:
CRISPR/Cas9
IL2 receptor γ
Small deletions
Immunodeficient mouse
Online Access:http://link.springer.com/article/10.1186/s42826-020-00048-y

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http://link.springer.com/article/10.1186/s42826-020-00048-y

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