Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation

Summary: ERK1c is an alternatively spliced isoform of ERK1 that specifically regulates mitotic Golgi fragmentation, which allows division of the Golgi during mitosis. We have previously shown that ERK1c translocates to the Golgi during mitosis where it is activated by a resident MEK1b to induce Golg...

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Bibliographic Details
Main Authors: Inbal Wortzel, Galia Maik-Rachline, Suresh Singh Yadav, Tamar Hanoch, Rony Seger
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006386