Constitutive Activation and Inactivation of Mutations Inducing Cell Surface Loss of Receptor and Impairing of Signal Transduction of Agonist-Stimulated Eel Follicle-Stimulating Hormone Receptor

Constitutive Activation and Inactivation of Mutations Inducing Cell Surface Loss of Receptor and Impairing of Signal Transduction of Agonist-Stimulated Eel Follicle-Stimulating Hormone Receptor

In the present study, we investigated the signal transduction of mutants of the eel follicle-stimulating hormone receptor (eelFSHR). Specifically, we examined the constitutively activating mutant D540G in the third intracellular loop, and four inactivating mutants (A193V, N195I, R546C, and A548V). T...

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Bibliographic Details
Main Authors: Munkhzaya Byambaragchaa, Jeong-Soo Kim, Hong-Kyu Park, Dae-Jung Kim, Sun-Mee Hong, Myung-Hwa Kang, Kwan-Sik Min
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
eelFSHR
constitutively activating mutation
inactivating mutation
cAMP response
signal transduction
cell surface loss of receptor
Online Access:https://www.mdpi.com/1422-0067/21/19/7075

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https://www.mdpi.com/1422-0067/21/19/7075

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