A Super-Clustering Approach for Fully Automated Single Particle Picking in Cryo-EM

A Super-Clustering Approach for Fully Automated Single Particle Picking in Cryo-EM

Structure determination of proteins and macromolecular complexes by single-particle cryo-electron microscopy (cryo-EM) is poised to revolutionize structural biology. An early challenging step in the cryo-EM pipeline is the detection and selection of particles from two-dimensional micrographs (partic...

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Bibliographic Details
Main Authors: Adil Al-Azzawi, Anes Ouadou, John J. Tanner, Jianlin Cheng
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Genes
Subjects:
super-clustering
intensity based clustering (IBC)
micrograph
cryo-EM
singe particle pickling
protein structure determination
k-means
fuzzy c-means (FCM)
Online Access:https://www.mdpi.com/2073-4425/10/9/666

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https://www.mdpi.com/2073-4425/10/9/666

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