RhoA/Rho-kinase and nitric oxide in vascular reactivity in rats with endotoxaemia.

RhoA/Rho-kinase (RhoA/ROK) pathway promotes vasoconstriction by calcium sensitivity mechanism. LPS causes nitric oxide (NO) overproduction to induce vascular hyporeactivity. Thus, we tried to examine the role of RhoA/ROK and NO in the regulation of vascular reactivity in different time-point of endo...

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Bibliographic Details
Main Authors: Mei-Hui Liao, Chih-Chin Shih, Cheng-Ming Tsao, Shiu-Jen Chen, Chin-Chen Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3574133?pdf=render