Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome

Abstract Background It is reported that growth hormone (GH) can alleviate oxidative stress (OS) induced apoptosis in some types of cells by activating the PI3K/Akt signaling pathway. This study investigated the role and underlying mechanism of GH in OS and apoptosis in granulosa cells (GCs) of patie...

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Bibliographic Details
Main Authors: Yan Gong, Shan Luo, Ping Fan, Huili Zhu, Yujing Li, Wei Huang
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Reproductive Biology and Endocrinology
Subjects:
Polycystic ovary syndrome
Growth hormone
Reactive oxygen species
Apoptosis
PI3K/Akt signaling
Online Access:https://doi.org/10.1186/s12958-020-00677-x

Internet

https://doi.org/10.1186/s12958-020-00677-x

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