Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms

Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms

WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ signalling pathway by alternate isoform expression. WWP2 isoforms select signal transducer Smad2/3 or inhibitor Smad7 substrates for degradation through different compositions of pr...

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Bibliographic Details
Main Authors: Lloyd C. Wahl, Jessica E. Watt, Hiu T. T. Yim, Danielle De Bourcier, James Tolchard, Surinder M. Soond, Tharin M. A. Blumenschein, Andrew Chantry
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
TGFβ signalling
transforming growth factor beta
smad
smad7
E3 ubiquitin ligase
NEDD4
WW domain
protein interaction
Online Access:https://www.mdpi.com/1422-0067/20/19/4682

Internet

https://www.mdpi.com/1422-0067/20/19/4682

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