Effect of valproic acid on extrinsic (DR4, DR5, FAS, FAS-L, TRAIL) and intrinsic (BAX, BAK and APAF1, Bcl-2, and Bcl-xL) apoptotic pathways, cell viability and apoptosis in hepatocellular carcinoma PLC/PRF5 cell line

Effect of valproic acid on extrinsic (DR4, DR5, FAS, FAS-L, TRAIL) and intrinsic (BAX, BAK and APAF1, Bcl-2, and Bcl-xL) apoptotic pathways, cell viability and apoptosis in hepatocellular carcinoma PLC/PRF5 cell line

Background: Histone acetylation and deacetylation play an important role in transcription and gene expression. The acetylation status of histones and non-histone proteins is determined by histone acetyl-transferases (HATs) and histone deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) ind...

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Bibliographic Details
Main Authors: Masumeh Sanaei, Fraidoon Kavoosi
Format: Article
Language:fas
Published: Kashan University of Medical Sciences and Health Services 2021-03-01
Series:Fiyz̤
Subjects:
valproic acid
apoptotic pathway
hepatocellular carcinoma
plc/prf5 cell line
Online Access:http://feyz.kaums.ac.ir/article-1-4142-en.html

Internet

http://feyz.kaums.ac.ir/article-1-4142-en.html

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