Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pathogenesis of multiple inflammatory and degenerative d...

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Bibliographic Details
Main Authors: Jing Zhao, Lei Zhang, Xiaodong Mu, Christelle Doebelin, William Nguyen, Callen Wallace, Daniel P Reay, Sara J McGowan, Lana Corbo, Paula R Clemens, Gabriela Mustata Wilson, Simon C Watkins, Laura A Solt, Michael D Cameron, Johnny Huard, Laura J Niedernhofer, Theodore M Kamenecka, Paul D Robbins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2004663

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https://doi.org/10.1371/journal.pbio.2004663

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