Synthesis and Biological Evaluation of Pyrimidine-oxazolidin-2-arylimino Hybrid Molecules as Antibacterial Agents

Synthesis and Biological Evaluation of Pyrimidine-oxazolidin-2-arylimino Hybrid Molecules as Antibacterial Agents

Pyrimidine-1,3-oxazolidin-2-arylimino hybrids have been synthesized as a new class of antibacterial agents. The synthetic approach exploits a Cu(II)-catalyzed intramolecular halkoxyhalogenation of alkynyl ureas, followed by a Suzuki coupling reaction with 2,4-dimethoxypyrimidin-5-boronic acid. Biolo...

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Bibliographic Details
Main Authors: Roberto Romeo, Maria A. Chiacchio, Agata Campisi, Giulia Monciino, Lucia Veltri, Daniela Iannazzo, Gianluigi Broggini, Salvatore V. Giofrè
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
intramolecular alkoxyhalogenation
Suzuki coupling
antibacterial compounds
pyrimidine-oxazolidinone hybrids
molecular docking
Online Access:http://www.mdpi.com/1420-3049/23/7/1754

Internet

http://www.mdpi.com/1420-3049/23/7/1754

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