Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF-κB pathway

Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF-κB pathway

Abstract Background Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the therapeutic approach to TC, but the effects are significantly inhibited by c...

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Bibliographic Details
Main Authors: Shi-Jian Yi, Yang Wu, Lan-Lan Li, Qian-Kun Liang, Yue Xiao
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Inflammation
Subjects:
Compound amino acid
Vitamin B6
Traumatic coagulopathy
Inflammatory response
HMGB1/TLR4/NF-κB signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12950-020-00258-0

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http://link.springer.com/article/10.1186/s12950-020-00258-0

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