Co-Spray Drying of Paracetamol and Propyphenazone with Polymeric Binders for Enabling Compaction and Stability Improvement in a Combination Tablet

Co-Spray Drying of Paracetamol and Propyphenazone with Polymeric Binders for Enabling Compaction and Stability Improvement in a Combination Tablet

Paracetamol (PCT) and propyphenazone (PRP) are analgesic drugs that are often combined in a single dosage form for enhanced pharmacological action. In this work, PCT and PRP were co-spray dried separately with hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) using drug suspensi...

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Bibliographic Details
Main Authors: Ioannis Partheniadis, Ioannis Nikolakakis, Constantinos K. Zacharis, Kyriakos Kachrimanis, Nizar Al-Zoubi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
combination therapy
spray drying
experimental design
thermal analysis
compressibility
diametrical loading
Online Access:https://www.mdpi.com/1999-4923/13/8/1259

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https://www.mdpi.com/1999-4923/13/8/1259

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