ExoU activates NF-κB and increases IL-8/KC secretion during Pseudomonas aeruginosa infection.

ExoU activates NF-κB and increases IL-8/KC secretion during Pseudomonas aeruginosa infection.

ExoU, a Pseudomonas aeruginosa cytotoxin injected into host cytosol by type III secretion system, exhibits a potent proinflammatory activity that leads to a marked recruitment of neutrophils to infected tissues. To evaluate the mechanisms that account for neutrophil infiltration, we investigated the...

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Main Authors: Carolina Diettrich Mallet de Lima, Teresa Cristina Calegari-Silva, Renata Meirelles Santos Pereira, Sabrina Alves de Oliveira Lima Santos, Ulisses Gazos Lopes, Maria-Cristina Maciel Plotkowski, Alessandra Mattos Saliba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3406076?pdf=render

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http://europepmc.org/articles/PMC3406076?pdf=render

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