Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

Abstract Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart of benign epithelial odontogenic tumor of ameloblastoma (AB) by the WHO classification. AC develops pulmonary metastasis in about one third of the patients and re...

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Bibliographic Details
Main Authors: Shohei Yoshimoto, Fumie Tanaka, Hiromitsu Morita, Akimitsu Hiraki, Shuichi Hashimoto
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Cancer Medicine
Subjects:
ameloblastoma
carcinogenesis
epithelial‐mesenchymal transition
odontogenic tumors
transforming growth factor beta
Online Access:https://doi.org/10.1002/cam4.2667

Internet

https://doi.org/10.1002/cam4.2667

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